After finding a host body in investigative reporter Eddie Brock, the alien symbiote must face a new enemy, Carnage, the alter ego of serial killer Cletus Kasady.

Investigative journalist Eddie Brock attempts a comeback following a scandal, but accidentally becomes the host of Venom, a violent, super powerful alien symbiote. Soon, he must rely on his newfound powers to protect the world from a shadowy organization looking for a symbiote of their own.

Eddie and Venom are on the run. Hunted by both of their worlds and with the net closing in, the duo are forced into a devastating decision that will bring the curtains down on Venom and Eddie's last dance.